- AC Milan and Liverpool have won a total of 13 European Cup titles
- Brest and Girona are making their first appearances in the competition
- Real Madrid kick off their quest for a record 16th championship
This week features a total of 18 matches, and here are the predicted scores for each Week One game.
Juventus v PSV (Tuesday, 5:45pm)
Juventus have not conceded a goal in Serie A this season yet, but they will take on a PSV side that has already scored 20 goals in their first five league matches.
Score prediction: Juventus 2-1 PSV
Young Boys v Aston Villa (Tuesday, 5:45pm)
Expect goals in this match, with Aston Villa scoring five in their last two games and Young Boys conceding 14 goals in their seven matches so far this season.
Score prediction: Young Boys 1-3 Aston Villa
Bayern Munich v Dinamo Zagreb (Tuesday, 8pm)
Bayern Munich come into this game after a convincing 6-1 away victory last weekend and with an impressive record of winning 28 out of their last 30 Champions League group stage matches.
Score prediction: Bayern Munich 4-0 Dinamo Zagreb
AC Milan v Liverpool (Tuesday, 8pm)
Both teams had different outcomes in their recent matches, with Liverpool losing to Nottingham Forest at home, while AC Milan secured a 4-0 win against Venezia. However, Milan has only won two of their last 11 Serie A matches.
Score prediction: AC Milan 1-2 Liverpool
Real Madrid v Stuttgart (Tuesday, 8pm)
Current champions Real Madrid have started the La Liga season unbeaten, with three wins and two draws, but they will face a Stuttgart side that has shown attacking prowess with seven goals in three league games.
Score prediction: Real Madrid 3-2 Stuttgart
Sporting v Lille (Tuesday, 8pm)
Portuguese champions Sporting have been in fine form, winning all of their first five matches and scoring a total of 19 goals. In contrast, Lille have suffered defeats in their last three games.
Score prediction: Sporting 4-1 Lille
Bologna v Shakhtar Donetsk (Wednesday, 5:45pm)
Bologna has had a slow start to their Serie A campaign, failing to win any of their first four league games and currently sitting in 17th place. Shakhtar Donetsk, on the other hand, brings a wealth of Champions League experience to the table.
Score prediction: Bologna 0-1 Shakhtar Donetsk
Sparta Prague v Salzburg (Wednesday, 5:45pm)
Czech champions Sparta Prague remain unbeaten in their first seven domestic games, while Salzburg has won three and lost one of their initial four matches.
Score prediction: Sparta Prague 1-1 Salzburg
Celtic v Slovan Bratislava (Wednesday, 8pm)
Celtic's home form in the Champions League has not been the best, but they come into this game having won all six Scottish Premiership matches and conceding just one goal.
Score prediction: Celtic 2-1 Slovan Bratislava
Club Brugge v Borussia Dortmund (Wednesday, 8pm)
Borussia Dortmund dominated their previous meetings with Club Brugge in the 2020-21 Champions League, winning both encounters 3-0. Club Brugge has struggled to find the net in recent matchups.
Score prediction: Club Brugge 0-2 Borussia Dortmund
Man City v Inter Milan (Wednesday, 8pm)
This match-up is a rematch of the 2023 final, which was their only competitive meeting so far. Manchester City have begun the season strongly with four consecutive wins, while Inter Milan has recorded two wins and two draws in Serie A.
Score prediction: Man City 3-1 Inter Milan
PSG v Girona (Wednesday, 8pm)
PSG are in top form in Ligue 1, winning all four of their matches, including a 3-1 victory over Brest. On the other hand, Girona, currently seventh in LaLiga, are looking forward to their maiden European campaign.
Score prediction: PSG 2-0 Girona
Crvena zvezda v Benfica (Thursday, 5:45pm)
Crvena zvezda comes into this match with three consecutive clean sheets, while Benfica has struggled in their last four away games, failing to secure a win.
Score prediction: Crvena zvezda 1-0 Benfica
Feyenoord v Bayer Leverkusen (Thursday, 5:45pm)
Both teams have been potent in front of goal this season, with Feyenoord scoring 14 goals in their four matches and Bayer Leverkusen netting 15 goals in three Bundesliga games.
Score prediction: Feyenoord 1-3 Bayer Leverkusen
Atalanta v Arsenal (Thursday, 8pm)
Defending Europa League champions Atalanta come into this game fresh off a 3-2 win against Fiorentina, while Arsenal sits second in the Premier League after defeating Tottenham.
Score prediction: Atalanta 1-1 Arsenal
Atletico Madrid v Leipzig (Thursday, 8pm)
Leipzig won their only previous meeting with a 2-1 victory in Germany in 2020, but Atletico Madrid boasts an unbeaten record in their last 10 Champions League home games at the Wanda Metropolitano.
Score prediction: Atletico Madrid 2-1 Leipzig
Brest v Sturm Graz (Thursday, 8pm)
Brest heads into their inaugural Champions League contest with only one win from their first four league matches, while Sturm Graz currently leads the Austrian league standings.
Score prediction: Brest 1-1 Sturm Graz
Monaco v Barcelona (Thursday, 8pm)
Monaco sits third in Ligue 1 after a solid start, but Barcelona has been in red-hot form, winning all of their first five league games and scoring 17 goals in the process.
Score prediction: Monaco 0-2 Barcelona