Bournemouth faced a challenging period, with defeats to Manchester City in the FA Cup quarter-finals and a 2-1 loss at home to relegation-threatened Ipswich on Wednesday.
This marked their fourth loss in five Premier League matches, but a strong finish to the season could still see them in contention for European qualification.
In contrast, West Ham have little motivation left as their 1-0 defeat to Wolves midweek, a team currently below them in the table, has intensified the pressure on manager Graham Potter.
Team news
West Ham will check the fitness of Mohammed Kudus, while Crysencio Summerville and Michail Antonio are out.
Bournemouth will be without injured Marcus Tavernier, Enes Unal, and Luis Sinisterra. The top scorer Justin Kluivert is uncertain to play, and Julian Araujo is also facing a fitness assessment.
The stats
In eight of West Ham's last nine matches, there have been under 2.5 goals.
In five of Hammers' last six games, at least one team failed to score.
West Ham lost three of their last four home matches without scoring a goal.
Bournemouth lost four of their last five matches.
In the last six Premier League away games, five of the Cherries' matches had four or more goals.
Out of Bournemouth's last six games in all competitions, four ended in 2-1 defeats.
Prediction
Despite tough times for both West Ham and Bournemouth, the Cherries are considered strong favorites to win at the London Stadium.
This is despite only getting one point in their last five league matches - a 2-2 draw against Tottenham, where they squandered a 2-0 lead.
Recently, Bournemouth has struggled to keep clean sheets, with Ipswich scoring with both their shots on target in the 2-1 win on Wednesday.
West Ham's performance against Wolves suggests they might not exploit the vulnerability in Bournemouth's defense.
Scoring has been a challenge for the Hammers under Potter, with eight of their last nine matches having fewer than 2.5 goals.
Niclas Fullkrug, returning from injury, hit the woodwork with a header against Wolves, but West Ham only managed one shot on target. A 2-1 victory for Bournemouth looks promising in the correct-score market.
Bournemouth counts on the fitness of top goalscorer Justin Kluivert, supported by striker Evanilson and attacking midfielders Antoine Semenyo and David Brooks to test the home defense.
West Ham has lost three of their last four home games, with the only exception being a win against Leicester destined for the Championship. Another defeat in east London could be looming for them.